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cymbalta

CYMBALTA | Uses, Side Effects and Dosage

CYMBALTA | Uses, Side Effects and Dosage


Cymbalta (Duloxetine) Classification is a serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain and osteoarthritis.

 (In Arabic سيمبالتا كبسولات)

cymbalta

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Cymbalta 60 mg Capsules 

CYMBALTA 60 MG 28 CAP

Cymbalta 30 mg Capsules 

CYMBALTA 30 MG 28 TAB

 

What is the Active Ingredient of Cymbalta ? 

Duloxetine 

 

What are the therapeutic uses of Cymbalta ? 

1) Treats Major Depressive Disorder

2) Used in Generalized Anxiety Disorder

3) Used in diabetic peripheral neuropathy

4) Management of fibromyalgia

5) Management of chronic musculoskeletal pain

6) Management of osteoarthritis of the knee in adults.

7) Management of chronic lower back pain in adults.

8) Used in stress urinary incontinence in adult women.

9) Management of chemotherapy-induced peripheral neuropathy.

10) Management of stress urinary incontinence in adult men after prostatectomy until recovery is complete.

 

What is the adult dose of Cymbalta (Duloxetine) according to each indication ? 

Dose for Depression:

Initial dose: 20 mg to 30 mg orally 2 times a day
Maintenance dose: 60 mg per day, given either once a day OR 30 mg orally 2 times a day

Dose for Fibromyalgia:

Initial dose: 30 mg orally once a day for at least 1 week
Maintenance dose: 30 to 60 mg orally once a day.

Dose for Generalized Anxiety Disorder:

Initial dose: 60 mg orally once a day
Maintenance dose: 60 to 120 mg orally once a day
Maximum dose: 120 mg/day.

Dose for Pain:

Initial dose: 30 to 60 mg orally once a day
Maintenance dose: 60 mg orally once a day.

Dose for Neuropathic Pain:

Initial dose: 30 to 60 mg orally once a day
Maintenance dose: 60 mg orally once a day.

Dose for Chronic Pain:

Initial dose: 30 to 60 mg orally once a day
Maintenance dose: 60 mg orally once a day.

Geriatric Dose for Generalized Anxiety Disorder:

Initial dose: 30 mg orally once a day for at least 2 weeks
Maintenance dose: 60 mg orally once a day

Cymbalta and Children ? 

Usual Pediatric Dose for Generalized Anxiety Disorder:

7 to 17 years:
Initial dose: 30 mg orally once a day for at least 2 weeks
Maintenance dose: 30 to 60 mg orally once a day
Maximum dose: 120 mg/day.

Usual Pediatric Dose for Fibromyalgia:

13 years and older:
Initial dose: 30 mg orally once a day for at least 1 week
Maintenance dose: 30 to 60 mg orally once a day.

 

Mechanism of Action of Cymbalta 

Duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake. Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors.

 

What are the alternatives of Cymbalta in Egypt ? 

Cymbatex 30 mg caps | سيمباتكس 30 مجم

Cymbatex 60 mg caps | سيمباتكس 60 مجم

Adwitine 60 mg caps

Adwitine 30 mg caps 

Duloxeprin 30 mg Caps | دولوكسبرين 30 مجم 

Cymbatex 20 mg Caps | سيمباتكس 20 مجم كبسولات 

Karbalta 30 mg caps | كاربالتا 30 مجم كبسولات 

 

What are the precautions when taking Cymbalta (Duloxetine) ?

  • Take Cymbalta exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
  • Taking Cymbalta in higher doses or more often than prescribed will not make it more effective, and may increase side effects.
  • Swallow the capsule whole and do not crush, chew, break, or open it.
  • Take with or without food.
  • Your blood pressure will need to be checked often.
  • Your symptoms may not improve for up to 4 weeks. You may have unpleasant symptoms if you stop using Cymbalta suddenly. Ask your doctor before stopping the medicine.

 

What are the side effects of Cymbalta (Duloxetine) ? 

  • Nausea
  • Dry mouth
  • Constipation
  • Loss of Appetite
  • Tiredness
  • Drowsiness
  • Increased Sweating
  • Dizziness and lightheadedness
  • This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity.
  • fast heartbeat
  • Hallucinations
  • Loss of Coordination
  • Unexplained fever 
  • Unusual agitation/Restlessness

 

Cymbalta and Pregnancy ? 

Taking an SNRI antidepressant during late pregnancy could increase your risk of excessive bleeding after you give birth, and may cause serious medical complications in the baby. However, stopping the medicine may not be safe if you have a relapse of depression. Do not start or stop taking this medicine without asking your doctor.

 

Cymbalta and Breastfeeding ? 

If you are breastfeeding, tell your doctor if you notice drowsiness, feeding problems, and slow weight gain in the nursing baby.

 

See Also 

Brintellix For Depression

Cipralex Tablet

 

References
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