EBIXA (Memantine) For Treating Alzheimer’s disease
Ebixa is a medicine that contains the active substance memantine hydrochloride. It is available as tablets (10 mg) in Egypt. In Arabic إبيكسا أقراص
What is the Active Ingredient of Ebixa tablets ?
What are the Therapeutic Indications of Ebixa ?
Treatment of patients with moderate to severe Alzheimer’s disease.
Memantine is used to manage moderate to severe Alzheimer’s dementia.
A more recent systemic review and meta-analysis indicates that memantine is beneficial as a first line drug for the treatment of Alzheimer’s dementia.
Cholinesterase inhibitors may be added to memantine for further beneficial effects on behavioral symptoms and other symptoms of dementia
What is Ebixa tablets used for?
Ebixa is used to treat patients with moderate to severe Alzheimer’s disease.
Alzheimer’s disease is a type of dementia (a brain disorder) that gradually affects memory, intellectual ability and behaviour. Learn More about Alzheimer’s disease.
How is Ebixa used?
Treatment should be started and supervised by a doctor who has experience in the diagnosis and treatment of Alzheimer’s disease. Treatment should only be started if a caregiver is available who will regularly monitor the use of Ebixa by the patient.
What is the dosage of Ebixa Tab ?
The recommended treatment dose of 20 mg per day is achieved by a gradual increase of the
Memantine dose during the first 3 weeks of treatment. The treatment scheme is also
indicated on the treatment initiation pack. Take one tablet once a day.
What are the side effects of Ebixa tab (memantine hydrochloride) ?
- Elevated liver function tests
- Imbalance disorder
- Shortness of breath
- High blood pressure
- Drug hypersensitivity
Mechanism of Action of Ebixa medicine (memantine hydrochloride)
Continuous activation of the N-methyl-D-aspartate (NMDA) receptors in the central nervous system caused by glutamate is thought to cause some of the Alzheimer’s disease symptoms. This overactivation is thought to contribute to neurotoxicity due to the excitatory properties of glutamate. The pharmacological effect of memantine likely occurs via the drug’s behavior as an uncompetitive (open-channel) NMDA receptor antagonist, preventing glutamate action on this receptor. Memantine has a preference for the NMDA receptor-operated cation channels. Despite these antagonist effects, memantine has not been proven to prevent or retard the neurodegeneration seen in patients diagnosed with Alzheimer’s disease.
What are the drug interactions of Ebixa ?
In particular, Ebixa tablets may change the effects of the following medicines and their
dose may need to be adjusted by your doctor:
– amantadine, ketamine, dextromethorphan
– dantrolene, baclofen
– cimetidine, ranitidine, procainamide, quinidine, quinine, nicotine
– hydrochlorothiazide (or any combination with hydrochlorothiazide)
– anticholinergics (substances generally used to treat movement disorders or intestinal
– anticonvulsants (substances used to prevent and relieve seizures)
– barbiturates (substances generally used to induce sleep)
– dopaminergic agonists (substances such as L-dopa, bromocriptine)
– neuroleptics (substances used in the treatment of mental disorders)
– oral anticoagulants
Memantine and food
You should inform your doctor if you have recently changed or intend to change your diet
substantially (e.g. from normal diet to strict vegetarian diet) or if you are suffering from states
of renal tubulary acidosis (RTA, an excess of acid-forming substances in the blood due to
renal dysfunction (poor kidney function)) or severe infections of the urinary tract (structure
that carries urine), as your doctor may need to adjust the dose of your medicine.
Ebixa tablets and Pregnancy and Breastfeeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a
baby, ask your doctor or pharmacist for advice before taking this medicine.
The use of memantine in pregnant women is not recommended.
Women taking Memantine tablets should not breast-feed.
Memantine and Driving Cars
Your doctor will tell you whether your illness allows you to drive and to use machines safely.
Also, Memantine tablets may change your reactivity, making driving or operating machinery
What are the alternatives of Ebixa Tablets ?
What are the other Drugs that treats Alzheimer’s disease ? | Available in Egypt
What is Ebixa 10 mg Price in Egypt ?
Ebixa 10 mg 28 tablets 2 strips cost 290 EGP.